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In addition to diagnosis and management, recommended methods of infection control and environmental management of the pathogen are presented.

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20th-century Italian literature, especially the works of Calvino, Caproni, and Svevo, Italian surrealism (Bontempelli, Savinio, ).

Comparative literature, especially the works of Agamben, Benjamin, Blanchot, Heidegger, Lacan, and Perniola.

A history of treatment with antimicrobial or antineoplastic agents within the previous 8 weeks is present for the majority of patients.

In clinical practice, antimicrobial use is often considered part of the operative definition of CDI, but it is not included here because of occasional reports of CDI in the absence of antimicrobial use, usually in community‐acquired cases.

From the Department of Internal Medicine, Division of Infectious and Immunologic Diseases, University of California Davis Medical Center, Sacramento, California (S. Data reporting the decreased effectiveness of metronidazole in the treatment of severe disease have been published.

Veterans Affairs Hospital, and Infectious Disease Division, Department of Medicine, Loyola University Chicago Stritch School of Medicine, Maywood, Illinois (D. P.); and the Department of Microbiology, Leeds Teaching Hospitals National Health Service Trust and Institute of Molecular and Cellular Biology, University of Leeds, Leeds, United Kingdom (M. has been identified and has been responsible for more‐severe cases of disease worldwide.

The use of these guidelines can be impacted by the size of the institution and the resources, both financial and laboratory, available in the particular clinical setting.

The diagnosis of CDI should be based on a combination of clinical and laboratory findings.

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A case definition for the usual presentation of CDI includes the following findings: (1) the presence of diarrhea, defined as passage of 3 or more unformed stools in 24 or fewer consecutive hours or its toxins or colonoscopic or histopathologic findings demonstrating pseudomembranous colitis.

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